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Statin Therapy for Patients with Cardiovascular Disease

Clinical Basis

Cardiovascular disease is the leading cause of death in the United States. More than 85 million American adults have one or more type of cardiovascular disease.1 It is estimated that by 2030, more than 43 percent of Americans will have a form of cardiovascular disease.2

In 2011, the total cost of cardiovascular disease and stroke in the United States was estimated to be $320 billion. This total includes direct costs, such as the cost of physicians and other health professionals, hospital services, prescribed medications and home health care, as well as indirect costs due to loss of productivity from premature mortality.3

Important guidelines for your practice

The ACC/AHA guideline emphasizes that lifestyle modification remains a critical component of ASCVD reduction.4,5

Four groups most likely to benefit from statin therapy are identified as follows:3

  • Patients with any form of clinical ASCVD
  • Patients with primary LDL-C levels of 190mg per dL or greater
  • Patients with diabetes mellitus, 40 to 75 years of age, with LDL-C levels of 70 to 189mg per dL
  • Patients without diabetes, 40 to 75 years of age, with an estimated 10-year ASCVD risk at least 7.5 percent
  • Risk assessment for 10-year and lifetime risk is recommended using an updated ASCVD risk calculator (http://www.cvriskcalculator.com/)

1Mozaffarian et al., 2015

2Heidenreich et al., 2011

3AHRQ, National Quality Measures Clearinghouse

4ACC/AHA Release Updated Guideline on the Treatment of Blood Cholesterol to Reduce ASCVD Risk, Am Fam Physician. 2014 Aug 15;90(4):260-265

5Also see to the 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults, A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines, Stone NJ, et. al., Circulation, November 12, 2013.

6See section 4, Statin Treatment Recommendations in the 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults for a discussion of individual treatment options.

 

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